منابع مشابه
Controlling Myocyte cGMP
CGMP is a central intracellular second-messenger regulating numerous cellular functions. In the cardiac myocyte, cGMP mediates effects of nitric oxide and atrial natriuretic peptide, whereas its counterpart, cAMP, mediates catecholamine signaling. Each cyclic nucleotide has a corresponding primary targeted protein kinase, protein kinase (PK)A for cAMP, and PKG for cGMP. PKA stimulation is assoc...
متن کاملThe role of cGMP-dependent protein kinase in controlling cardiomyocyte cGMP.
The role of cGMP as a second messenger in physiological and pathophysiological processes is widely appreciated.1–3 The successes of drugs that target the cGMP-signaling pathway (nitrovasodilators and PDE5 inhibitors [sildenafil, tadalafil, vardenafil]) have inspired interest in other cardiovascular benefits that might derive from a better understanding of this pathway.2,4–7 Elevation of cGMP in...
متن کاملRole of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility.
Previous studies have demonstrated the existence of a circulating myocardial depressant substance during human septic shock. We have recently identified this substance as a synergistic combination of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This study utilized an in vitro cardiac myocyte assay to evaluate the potential mechanistic role of nitric oxide (NO) and cGMP in depress...
متن کاملcGMP level that reduces cardiac myocyte O2 consumption is altered in renal hypertension.
We tested the hypothesis that cardiac myocytes from hypertensive (one kidney, one clip; 1K,1C) cardiac-hypertrophied rabbits require higher guanosine 3',5'-cyclic monophosphate (cGMP) to similarly lower O2consumption than control myocytes and that this effect is caused by differences in guanylate cyclase activity. Using isolated myocytes from control and 1K,1C New Zealand White rabbits, we obta...
متن کاملControlling anoxic tolerance in adult Drosophila via the cGMP-PKG pathway.
In this study we identify a cGMP-dependent protein kinase (PKG) cascade as a biochemical pathway critical for controlling low-oxygen tolerance in the adult fruit fly, Drosophila melanogaster. Even though adult Drosophila can survive in 0% oxygen (anoxia) environments for hours, air with less than 2% oxygen rapidly induces locomotory failure resulting in an anoxic coma. We use natural genetic va...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2009
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.109.209700